The Coalition for Children Affected by AIDS has produced a brief on what donors, policy makers, implementers and civil society can do to deliver integrated support for children and adolescents affected by HIV and AIDS. Those who face social and structural exclusion must be prioritised if we are to achieve HIV targets and broader SDGs. The most vulnerable are beyond the reach of mainstream services – that must change. Combining services and support in a comprehensive programme achieves far more and uses fewer resources. The Nurturing Care Framework can transform the life course of these children.